Monoclonal Antibody Generation
Recombinant Antibodies (Single B Cell Approach) - Rabbit (Oryctolagus cuniculus)
Rabbit (Oryctolagus cuniculus)
Overview
LAMPIRE’s Rabbit Monoclonal platform delivers high specificity antibodies with reduced off target effects by leveraging the natural strengths of the rabbit immune system. Rabbit antibodies consistently exhibit higher affinity and broader epitope recognition than traditional murine models, making them well suited for challenging targets and sensitive assay applications.
Using an integrated single B cell workflow, LAMPIRE supports rabbit monoclonal discovery from immunization through recombinant expression. Antigen specific B cell isolation and direct sequence recovery enable a transparent, sequence forward approach, with all validated sequences delivered to the client with full IP ownership and flexibility for downstream development.
Rabbit Bcell, Monoclonal Rabbit Antibodies Snapshot
Why Choose Us?
High - Affinity Antibodies
Antigen-Specific B Cell Isolation
Paired VH and VK Sequences
End-To-End Workflow
US-Based, AAALAC accredited
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Benefits
Rabbit antibodies deliver superior affinity and reach challenging targets with ease. Paired sequence insight and flexible expression maximize performance and long‑term value.
Higher Affinity Performance Ultralong CDR3 knob domains enable engagement of complex or recessed antigen surfaces that are often inaccessible to conventional antibody formats.
Effective Against Difficult Targets The rabbit immune response is well suited for small, conserved, or low immunogenic epitopes that can be challenging for other hosts.
Sequence Forward Transparency Direct recovery of paired VH and VK sequences provides full visibility and long term value through client owned IP.
Flexible Recombinant Options Recovered antibodies can be expressed in multiple recombinant formats with scalable production to support screening and development.
Capabilities
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Scientific Review | White Papers | Sell Sheet | Forms
Why Choose Advanced Screening Solutions?
Benefit from our team’s extensive expertise in advanced screening techniques, stay ahead of the curve with access to cutting-edge technologies and innovative methodologies, and achieve actionable, results-driven insights that propel your research forward and accelerate drug discovery processes.
Epitope Binning
Advanced Mapping:
Employ "bi-directional" matrix competition for epitope binning, identifying both competing and non-competing epitopes.
Novel Discoveries:
Uncover novel epitopes and assess overlap or establish novelty by including patented or published mAbs into the matrix.
Tailored Solutions: Customize assays to meet your specific needs and explore new avenues in target characterization.
Kinetic Analysis
Detailed Understanding:
Rank off-rates at single concentration or delve into full KD kinetics for comprehensive understanding. Identfy High Affinity Binders with superior selectivity.
High-Performance Systems: Leverage the Biacore SPR T200 system or Octet BLI for precise kinetic analysis.
Target Binding on Cells
Precise Measurement:
Determine single concentration or EC50 against target overexpressing cells compared to control cells.
Comprehensive Analysis:
Conduct on-cell binding, antibody competition, internalization, and bespoke functional assays for unparalleled insights.
State-of-the-Art Equipment:
Utilize the Sartorius iQue flow cytometer for high-throughput and accurate results.
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