Monoclonal Antibody Generation

Recombinant Antibodies (Single B Cell Approach) - Bovine (Bos Taurus)
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Bovine (Bos taurus)

Overview

LAMPIRE’s Bovine Picobody platform enables the discovery of uniquely structured binding domains through advanced single B cell sorting and directed sequencing of bovine ultralong CDR3 antibodies. Found only in bovines, picobodies are ultra-small (3–5 kDa), disulfide-stabilized knob domains capable of accessing challenging epitopes often unreachable by conventional antibody formats. This emerging technology supports the development of next-generation recombinant antibody formats, including knobbodies and bispecific antibodies for therapeutic and diagnostic applications.

Service Details

Our platform combines precision single B cell isolation with targeted ultralong CDR3 sequence recovery to preserve natural bovine immune diversity while eliminating library bias. Picobody candidates are derived from compact knob domains supported by flexible stalk regions, enabling precise interaction with complex antigen surfaces. All recovered sequences are delivered with full client IP ownership and can be advanced into recombinant expression, characterization, and engineering workflows. LAMPIRE’s approach provides a streamlined path for exploring novel bovine-derived binders with exceptional stability, structural diversity, and promising preclinical potential against viral and cancer-associated targets.

Bovine Ultra Long CDR3 Picobody Single Bcell Sorting

Lampire Bovine Monoclonal Antibody Generation Flow Chart

Why Choose Us?

LAMPIRE unlocks access to a rare bovine antibody repertoire through a sequence-forward discovery approach. Our platform delivers direct, unbiased sequence recovery with full client IP ownership and a clear path into advanced recombinant formats.

Access to a rare and highly differentiated bovine antibody repertoire

Direct sequence recovery with full transparency and client owned IP

Sequence forward discovery without library generation or panning bias

Experience translating novel binding domains into advanced recombinant formats

US based, AAALAC accredited facilities with quality oversight

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Benefits

Rabbit antibodies deliver superior affinity and reach challenging targets with ease. Paired sequence insight and flexible expression maximize performance and long‑term value.

Expanded Epitope Access Ultralong CDR3 knob domains enable engagement of complex or recessed antigen surfaces that are often inaccessible to conventional antibody formats.

Compact Domains with Engineering Flexibility Picobodies are exceptionally small yet stable, supporting flexible engineering into advanced recombinant formats such as knobbody and bispecific designs.

Confident Selection Optional binding and characterization workflows support early evaluation of specificity and differentiation to guide downstream decisions.

Transparency and Control Direct sequence recovery with full client IP ownership ensures clear handoff into engineering and development.

Capabilities

LAMPIRE provides an end-to-end platform for bovine picobody discovery, from immunization and B cell isolation to sequencing, expression, and screening.

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Why Choose Advanced Screening Solutions?

Benefit from our team’s extensive expertise in advanced screening techniques, stay ahead of the curve with access to cutting-edge technologies and innovative methodologies, and achieve actionable, results-driven insights that propel your research forward and accelerate drug discovery processes.

Epitope Binning

Advanced Mapping:
Employ "bi-directional" matrix competition for epitope binning, identifying both competing and non-competing epitopes.

Novel Discoveries:
Uncover novel epitopes and assess overlap or establish novelty by including patented or published mAbs into the matrix.

Tailored Solutions: Customize assays to meet your specific needs and explore new avenues in target characterization.

Kinetic Analysis

Detailed Understanding:
Rank off-rates at single concentration or delve into full KD kinetics for comprehensive understanding. Identfy High Affinity Binders with superior selectivity.

High-Performance Systems: Leverage the Biacore SPR T200 system or Octet BLI for precise kinetic analysis.

Target Binding on Cells

Precise Measurement:
Determine single concentration or EC50 against target overexpressing cells compared to control cells.

Comprehensive Analysis:
Conduct on-cell binding, antibody competition, internalization, and bespoke functional assays for unparalleled insights.

State-of-the-Art Equipment:
Utilize the Sartorius iQue flow cytometer for high-throughput and accurate results.

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