Monoclonal Antibody Generation
Recombinant Antibodies (Single B Cell Approach) - Llama (Lama glama)
Llama (Lama glama)
Overview
LAMPIRE’s Llama vHH platform enables rapid discovery of single-domain antibodies (nanobodies) using proprietary single B cell sorting of antigen-positive llama and alpaca B cells. By combining camelid immunization expertise with advanced B cell technologies, we provide a streamlined path to highly specific and stable vHH binders for research, diagnostic, and therapeutic applications.
The sequence-forward vHH discovery approach delivers epitope-diverse nanobody candidates with strong biophysical properties while eliminating the bias of library-based methods. Multiple immunization sampling timepoints drive deeper affinity maturation, and direct sequence recovery ensures full transparency and client ownership of all IP for rapid downstream development.
Llama (Lama glama)
Overview
LAMPIRE’s Llama vHH platform enables rapid discovery of single-domain antibodies (nanobodies) using proprietary single B cell sorting of antigen-positive llama and alpaca B cells. By combining camelid immunization expertise with advanced B cell technologies, we provide a streamlined path to highly specific and stable vHH binders for research, diagnostic, and therapeutic applications.
The sequence-forward vHH discovery approach delivers epitope-diverse nanobody candidates with strong biophysical properties while eliminating the bias of library-based methods. Multiple immunization sampling timepoints drive deeper affinity maturation, and direct sequence recovery ensures full transparency and client ownership of all IP for rapid downstream development.
Single B-Cell Discovery Platform Snapshot
Why Choose Us?
Rapid vHH discovery using proprietary single B cell sorting technology
Full capture of native immune repertoire and clonotype diversity
Faster timelines by eliminating traditional library generation and panning
In silico developability, human-ness, and immunogenicity assessments
Optional humanization and sequence optimization for therapeutic development
US based, AAALAC accredited facilities with quality oversight
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Benefits
Rapid Binder Discovery
Single B cell sorting enables fast sequence recovery from antigen-specific B cells without traditional library construction.
Native Immune Diversity
Captures the full antibody repertoire generated during immunization, improving diversity and lead selection.
Efficient Screening Workflow
Removes duplicate clones early and eliminates display library generation to accelerate discovery.
Supporting Therapeutic Development
In silico assessments and optional humanization help prepare nanobody candidates for downstream development.
Capabilities
From small-scale research projects to large-scale production, we deliver high-quality monoclonal antibodies to drive your scientific advancements.
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Scientific Review | White Papers | Sell Sheet | Forms
Why Choose Advanced Screening Solutions?
Benefit from our team’s extensive expertise in advanced screening techniques, stay ahead of the curve with access to cutting-edge technologies and innovative methodologies, and achieve actionable, results-driven insights that propel your research forward and accelerate drug discovery processes.
Epitope Binning
Advanced Mapping:
Employ "bi-directional" matrix competition for epitope binning, identifying both competing and non-competing epitopes.
Novel Discoveries:
Uncover novel epitopes and assess overlap or establish novelty by including patented or published mAbs into the matrix.
Tailored Solutions: Customize assays to meet your specific needs and explore new avenues in target characterization.
Kinetic Analysis
Detailed Understanding:
Rank off-rates at single concentration or delve into full KD kinetics for comprehensive understanding. Identfy High Affinity Binders with superior selectivity.
High-Performance Systems: Leverage the Biacore SPR T200 system or Octet BLI for precise kinetic analysis.
Target Binding on Cells
Precise Measurement:
Determine single concentration or EC50 against target overexpressing cells compared to control cells.
Comprehensive Analysis:
Conduct on-cell binding, antibody competition, internalization, and bespoke functional assays for unparalleled insights.
State-of-the-Art Equipment:
Utilize the Sartorius iQue flow cytometer for high-throughput and accurate results.
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