Monoclonal Antibody Generation
Recombinant Antibodies (Single B Cell Approach) - Rabbit
RAbbit Recombinant Antibodies
Overview
LAMPIRE’s Rabbit Monoclonal platform delivers high specificity antibodies with reduced off target effects by leveraging the natural strengths of the rabbit immune system. Rabbit antibodies consistently exhibit higher affinity and broader epitope recognition than traditional murine models, making them well suited for challenging targets and sensitive assay applications.
Using an integrated single B cell workflow, LAMPIRE supports rabbit monoclonal discovery from immunization through recombinant expression. Antigen specific B cell isolation and direct sequence recovery enable a transparent, sequence forward approach, with all validated sequences delivered to the client with full IP ownership and flexibility for downstream development.
Why Choose Us?
High affinity rabbit antibodies with broad epitope recognition and reduced off target effects
Antigen specific B cell isolation using precision FACS analysis
Faster timelines by eliminating traditional library generation and panning
Direct recovery of paired VH and VK sequences with full client IP ownership
End to end workflow from immunization through recombinant expression
US based, AAALAC accredited facilities with quality oversight
Capabilities
- Custom rabbit immunization campaigns tailored to antigen type and project goals
- Support for diverse antigen formats including proteins, peptides, soluble membrane proteins, nanodiscs, and VLPs
- Antigen specific B cell isolation from PBMCs and splenocytes
- Next generation sequencing based recovery of paired VH and VK sequences
- Transient CHO expression with scalable yields from microgram to gram quantities
- Primary binding confirmation using ELISA with positive and negative controls
Benefits
Higher Affinity Performance
Ultralong CDR3 knob domains enable engagement of complex or recessed antigen surfaces that are often inaccessible to conventional antibody formats.
Effective Against Difficult Targets
The rabbit immune response is well suited for small, conserved, or low immunogenic epitopes that can be challenging for other hosts.
Sequence Forward Transparency
Direct recovery of paired VH and VK sequences provides full visibility and long term value through client owned IP.
Flexible Recombinant Options
Recovered antibodies can be expressed in multiple recombinant formats with scalable production to support screening and development.
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